DENR controls JAK2 translation to induce PD-L1 expression for tumor immune evasion

DENR controls JAK2 translation to induce PD-L1 expression for tumor immune evasion

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Several mechanisms have been associated with transcriptional and post-transcriptional regulation of Stocking PD-L1 in cancer.Here the authors show that a RNA binding protein, DENR, positively regulates the translation of JAK2 and induces PD-L1 expression Magnet in tumor cells, associated with immune evasion.